Inflammation- Histamine action

A 20-year-old boy presents to the physician complaining of shortness of breath. He is a known asthmatic and has a history of allergies and respiratory infections. He regularly uses a spray to relieve his asthmatic exacerbations. During the flare-up of his symptoms, which of the following preformed substances is released from mast cells and platelets, resulting in increased vascular permeability in the lungs of the patient?