Hematology- Alpha thalassemia

A 20-year-old primigravida gives birth at 34 weeks gestation to a male infant. On physical examination, the infant is markedly hydropic. Laboratory studies show his hematocrit is 18 %, and the peripheral blood smear reveals numerous nucleated red blood cells and a few erythroblasts. The red blood cells reveal marked microcytosis, anisocytosis and poikilocytosis. Which […]

Hematology- Hemolytic anemia general features

A 75-year-old woman has developed increasing difficulty breathing for the past 2 weeks. On physical examination, she has diffuse rales in all lung fields. Scleral icterus is noted. A complete blood count shows hemoglobin 7.4 g/dl, hematocrit 22.4%, MCV 92 fL, platelet count 200,000/microliter and total WBC count 6800/microliter with a differential count of 60% […]

Hematology- Lead poisoning

A 12-year-old girl has had increasing sluggishness and poorer school performance over the past year. There is no history of increased numbers of infections. The child now complains of headaches. There is no hepatosplenomegaly or lymphadenopathy. A complete blood count shows: Hgb 11.8 g/dL, Hct 32.8%, MCV 70 fL, platelet count 290,000/microliter, and total WBC […]

Hematology- splenectomy howell jolly bodies

An 18-year-old healthy man suffers blunt force trauma to the abdomen in a motor vehicle accident. On physical examination, he has upper abdominal tenderness. An abdominal CT scan reveals a splenic hematoma. At laparotomy, a splenectomy is performed. Following splenectomy, which of the following peripheral blood morphologic findings is most likely present?

Hematology- PRCA

A 45-year-old woman presents to the clinician for evaluation of her progressively increasing weakness and dyspnea for the past 3 months. In addition, she has had dysphagia for 2 months, initially for solid foods, which gradually progressed to liquid foods. On examination, her temperature is 37.2 C, pulse rate is 90/min, respirations 18/min and blood […]

Hematology- IM

A 16-year-old boy comes to the clinic complaining of fever and malaise for the past 2 days. On examination, his temperature is 37.8 °C with tender cervical lymphadenopathy. Laboratory studies show hemoglobin 12.5 g/dL, platelet count 225,000/cumm and WBC count 12500/cumm. His peripheral blood smear shows frequent atypical lymphocytes. These atypical cells express which of […]

Hematology- ACD

A 38-year-old woman presents to her primary care physician with a 6-month history of fatigue. However, in the past week, she has begun feeling short of breath, even walking to the grocery store, something she was able to do easily before. She also reports a history of rheumatoid arthritis, for which she takes prescribed pain […]

Hematology- MM

A 65-year-old man comes to the clinic for evaluation of worsening fatigue and back pain for 4 months. He reports frequent streptococcal respiratory infections in the past 6 months. He takes no medications and has no positive family history. On examination, vital signs are normal, but there is a presence of pitting edema on the […]