SCC- Paraneoplastic cause
Mechanism of the paraneoplastic syndrome in a patient with squamous cell carcinoma lung?
Subject: Neoplasia
Neoplasia- BCL2 function
The Human B-cell lymphoma gene (BCL-2) was historically discovered as the gene located near the junction at which chromosomes 18 and 14 (t14;18) are joined anomalously in the tumor cells of follicular lymphoma patients. This chromosome translocation leads to misregulation of the normal BCL-2 expression pattern to contribute to cancer. Constitutive overexpression of the protein […]
Neoplasia- 9;22
A 70-year-old man presented to his primary care physician with 2 months of fatigue and a 10-pound weight loss. He noted a general sense of malaise. On physical examination, the clinician could palpate the spleen 4 cm below the costal margin but noted no palpable lymphadenopathy. Family history was noncontributory. The CBC reveals marked leukocytosis […]
Neoplasia- Asbestos- mesothelioma
A 70-year old male presents to your clinic complaining of chest discomfort, malaise, fever, night sweats and weight loss of 8.2 kg (18lbs). He had worked in a shipyard most of his adult life. A chest X-ray reveals a large pleural effusion and lung tissue biopsy confirms a malignant pleural mesothelium tumor. Which of the […]
Neoplasia- Desmoplasia
A 55-year old female undergoes a biopsy for a breast lump and is subsequently diagnosed with cancer. The microscopy of the tumor biopsy shows evidence of dense and abundant collagen-rich ECM secreted by fibroblasts and myofibroblasts. Which of the following best describes this change in the patient’s cancer?
Neoplasia- E cadherin loss
A 65-year old male is diagnosed with metastatic prostate cancer which is also chemoresistant. Reduced expression of which of the following is expected to be seen in the neoplastic cells?
Neoplasia- CIS defn
A 45-year old female comes to your clinic for routine PAP smear screening. The PAP smear indicates a high-grade squamous intraepithelial lesion. A biopsy is performed and results show full thickness dysplasia with an intact basement membrane in the cervical epithelium. Which of the following terms best describes this cervical lesion?
Neoplasia- APC function
The normal product of the APC gene primarily regulates which of the following cell behaviors?
Neoplasia- BCC= sunlight
A 75-year-old male presents to your clinic concerned about a pearly papule on his upper lip. The histopathology report suggests a diagnosis of basal cell carcinoma. Exposure to which of the following is strongly correlated with a high incidence of this malignancy?
Neoplasia- ovarian cystic teratoma
A 23-year-old African American female presents to your outpatient clinic complaining of abdominal distension and pain of 3 weeks duration. She was diagnosed with constipation 1 week before presentation for which she was taking stool softener resulting in bowel movement every 2 days. Review of systems is positive for heavy menses since menarche, which started […]
